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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIK1 All Species: 7.27
Human Site: S674 Identified Species: 13.33
UniProt: P57059 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57059 NP_775490.2 783 84902 S674 P A A A P G C S Q A P Q P A P
Chimpanzee Pan troglodytes XP_531484 783 84972 S674 P A A A P G C S Q A P Q P A P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544912 898 97147 Q799 P A G P P G C Q Q A A P L V L
Cat Felis silvestris
Mouse Mus musculus Q60670 779 85009 Q678 A A A S S G C Q Q G P Q L S P
Rat Rattus norvegicus Q9R1U5 776 84890 Q675 S A V S S D Y Q Q A P Q L S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511894 801 88312 P683 P Q A P A G I P P G P Q P P P
Chicken Gallus gallus Q9IA88 798 88848 C694 P S D S A G T C K A S N S L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 L887 P S A L Q Q A L L S P T P L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_569972 1398 149888 P1255 F G H S L G P P P P P A P A P
Honey Bee Apis mellifera XP_397175 718 80391 V641 P P L S Q G H V D R D F D R E
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 S928 P S S S S S S S T N P P H Q H
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 P435 N M K C R W V P G L A D G Q N
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 T556 K Y D I G N K T N T N E K I P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 69.2 N.A. 81.3 81.6 N.A. 70.4 66.6 N.A. 32 N.A. 28.8 36.5 24.5 N.A.
Protein Similarity: 100 99.6 N.A. 73.6 N.A. 86.2 86.3 N.A. 77 76.6 N.A. 44 N.A. 38 50.9 39.4 N.A.
P-Site Identity: 100 100 N.A. 46.6 N.A. 53.3 40 N.A. 46.6 20 N.A. 26.6 N.A. 33.3 13.3 20 N.A.
P-Site Similarity: 100 100 N.A. 46.6 N.A. 66.6 53.3 N.A. 46.6 40 N.A. 40 N.A. 40 20 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.2 27.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41 42.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 39 39 16 16 0 8 0 0 39 16 8 0 24 0 % A
% Cys: 0 0 0 8 0 0 31 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 16 0 0 8 0 0 8 0 8 8 8 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 16 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 8 8 0 8 62 0 0 8 16 0 0 8 0 0 % G
% His: 0 0 8 0 0 0 8 0 0 0 0 0 8 0 8 % H
% Ile: 0 0 0 8 0 0 8 0 0 0 0 0 0 8 0 % I
% Lys: 8 0 8 0 0 0 8 0 8 0 0 0 8 0 0 % K
% Leu: 0 0 8 8 8 0 0 8 8 8 0 0 24 16 16 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 8 0 0 8 8 8 8 0 0 8 % N
% Pro: 62 8 0 16 24 0 8 24 16 8 62 16 39 8 54 % P
% Gln: 0 8 0 0 16 8 0 24 39 0 0 39 0 16 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 8 0 0 0 8 0 % R
% Ser: 8 24 8 47 24 8 8 24 0 8 8 0 8 16 0 % S
% Thr: 0 0 0 0 0 0 8 8 8 8 0 8 0 0 0 % T
% Val: 0 0 8 0 0 0 8 8 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _